Absorption Band Q Model for the Earth

Body wave, surface wave, and normal mode data are used to place constraints on the frequency dependence of Q in the mantle. With a simple absorption band model it is possible to satisfy the shear sensitive data over a broad frequency range. The quality factor Q_s (ω) is proportional to ω^α in the band and to ω and ω^(−1) at higher and lower frequencies, respectively, as appropriate for a relaxation mechanism with a spectrum of relaxation times. The parameters of the band are Q(min) = 80, α = 0.15, and width, 5 decades. The center of the band varies from 10^1 seconds in the upper mantle, to 1.6×10^3 seconds in the lower mantle. The shift of the band with depth is consistent with the expected effects of temperature, pressure and stress. High Q_s regions of the mantle are attributed to a shift of the absorption band to longer periods. To satisfy the gravest fundamental spheroidal modes and the ScS data, the absorption band must shift back into the short-period seismic band at the base of the mantle. This may be due to a high temperature gradient or high shear stresses. A preliminary attempt is also made to specify bulk dissipation in the mantle and core. Specific features of the absorption band model are low Q in the body wave band at both the top and the base of the mantle, low Q for long-period body waves in the outer core, an inner core Q_s that increases with period, and low Q_P/Q_S at short periods in the middle mantle. The short-period Q_s increases rapidly at 400 km and is relatively constant from this depth to 2400 km. The deformational Q of the earth at a period of 14 months is predicted to be 463

Implications of Current Federal Aviation Regulatory Policies Governing Low Time Commercial Pilots who Transition to Single Pilot/IFR Environments

The purpose of this study was to investigate the need to change FAA policy governing commercial pilot training and experience by soliciting the expertise from chief pilots and directors of flight operations who were members of the National Air Transportation Association (NATA). A descriptive survey questionnaire was specifically developed for this study to investigate attitudes and beliefs about the adequacy of a commercial pilot new hire\u27s previous flight experience. The study found that a substantial number of aviation professionals believe that a new hire\u27s previous pilot-in-command (PIC) experience in a single-pilot environment is inadequate. Major concerns include inadequate previous experience as PIC in a single pilot environment flying high performance multi-engine aircraft, inadequate instrument meteorological conditions (IMC) experience, substandard IMC experience at night, inadequate mountainous experience, and inadequate flight experience in hazardous conditions (icing conditions, slippery runways, etc.). Quality of flight time and experience were addressed as it related to commercial pilots. Recommendations were made to change existing FAA policies for new hire commercial pilots who transition to single pilot, multi-engine charter operations without any prior experience

Residual tumor cells that drive disease relapse after chemotherapy do not have enhanced tumor initiating capacity.

Although chemotherapy is used to treat most advanced solid tumors, recurrent disease is still the major cause of cancer-related mortality. Cancer stem cells (CSCs) have been the focus of intense research in recent years because they provide a possible explanation for disease relapse. However, the precise role of CSCs in recurrent disease remains poorly understood and surprisingly little attention has been focused on studying the cells responsible for re-initiating tumor growth within the original host after chemotherapy treatment. We utilized both xenograft and genetically engineered mouse models of non-small cell lung cancer (NSCLC) to characterize the residual tumor cells that survive chemotherapy treatment and go on to cause tumor regrowth, which we refer to as tumor re-initiating cells (TRICs). We set out to determine whether TRICs display characteristics of CSCs, and whether assays used to define CSCs also provide an accurate readout of a cell's ability to cause tumor recurrence. We did not find consistent enrichment of CSC marker positive cells or enhanced tumor initiating potential in TRICs. However, TRICs from all models do appear to be in EMT, a state that has been linked to chemoresistance in numerous types of cancer. Thus, the standard CSC assays may not accurately reflect a cell's ability to drive disease recurrence

WHEN TRAINING GETS TRUMPED: HOW DUAL-TASK INTERFERENCE INHIBITS SECURITY TRAINING

Security training programs are an important intervention to protect users and organizations against security threats. Unfortunately, users often ignore their training and engage in poor security behaviors. We explain how dual-task interference (DTI) is a primary cause of security training disregard. DTI is a cognitive limitation wherein humans cannot perform more than one task simultaneously without experiencing a deterioration of performance. In our context, we hypothesize how prompting users to perform security behaviors during high-DTI times may derail one’s previous security training, resulting in less secure behaviors. We test our hypotheses in an experiment that compares users’ adherence to security training during low-DTI and high-DTI times in a realistic context. We found that performing security behaviors during low-DTI times increased adherence to prior security training by 31% compared to performing behaviors during high-DTI times. The results have implications for using DTI as a theoretical framework for understanding security behaviors, prompting users to perform security behaviors during times that will maximize adherence to past security training, and considering humans’ neurological limitations when designing security training and intervention programs

Mrgprd Enhances Excitability in Specific Populations of Cutaneous Murine Polymodal Nociceptors

The Mas-related G protein-coupled receptor D (Mrgprd) is selectively expressed in nonpeptidergic nociceptors that innervate the outer layers of mammalian skin. The function of Mrgprd in nociceptive neurons and the physiologically relevant somatosensory stimuli that activate Mrgprd^-expressing (Mrgprd^+) neurons are currently unknown. To address these issues, we studied three Mrgprd knock-in mouse lines using an ex vivo somatosensory preparation to examine the role of the Mrgprd receptor and Mrgprd+ afferents in cutaneous somatosensation. In mouse hairy skin, Mrgprd, as marked by expression of green fluorescent protein reporters, was expressed predominantly in the population of nonpeptidergic, TRPV1-negative, C-polymodal nociceptors. In mice lacking Mrgprd, this population of nociceptors exhibited decreased sensitivity to cold, heat, and mechanical stimuli. Additionally, in vitro patch-clamp studies were performed on cultured dorsal root ganglion neurons from Mrgprd^(–/–) and Mrgprd^(+/–) mice. These studies revealed a higher rheobase in neurons from Mrgprd^(–/–) mice than from Mrgprd^(+/–) mice. Furthermore, the application of the Mrgprd ligand β-alanine significantly reduced the rheobase and increased the firing rate in neurons from Mrgprd^(+/–) mice but was without effect in neurons from Mrgprd^(–/–) mice. Our results demonstrate that Mrgprd influences the excitability of polymodal nonpeptidergic nociceptors to mechanical and thermal stimuli

A Comprehensive Economic Stimulus for our Failing Economy

This paper presents a comprehensive plan to fix the ailing American economy, through a five-step approach. First, the Federal Reserve must continue to broaden the scope of monetary policy, by purchasing and selling long-term securities. Manipulating expectations through FOMC statements is another tool at the Federal Reserve’s disposal. Secondly, the government must enact fiscal stimulus to stabilize the economy in the short and medium runs, through investment in infrastructure projects, green technology, fusion technology, and science education. Additionally, the new fiscal policy must tackle the mortgage meltdown, which is weighing down the entire economy. Third, the regulatory system must be changed to reduce the likelihood of another financial collapse, starting with the nationalization of the ratings agencies. Ratings should be updated faster, with a numeric grading system rather than the pre-existing letter grades. Fourth, our globalized economy insures that a coordinated globalized response is necessary to recover. Global cooperation to reduce inflation and avoid protectionist policies is vital. Finally, the American bailout policy must be made clear, only giving bailouts to companies that are sound but financially strapped and those that are too big to fail